关键词: 心肌梗塞, 胶原, 血管紧张素Ⅱ, 疾病模型, 动物

Abstract: Objective To investigate the effects of valsartan on experimental left ventricular collagen remodeling (LVRM) in rats with myocardial infarction (MI). Methods Ligate anterior descending branches of coronary artery of Sprague-Dawley rats were used to establish models of acute myocardial infarction (AMI). Seventy rats were randomly divided into 6 groups:①Sham groups:including Sham 1(n=5) and Sham 4(n=5).The pericardium of rats in Sham groups were cut open and sutured immediately. The rats were routinely breeded for 1 week and 4 weeks,respectively, 1.5 mL saline was poured into stomach of rats once a day;②Control groups:AMI 1 (n=10) and AMI 4 (n=10). 1.5 mL saline was poured into stomach of rats with AMI once a day for 1 week and 4 weeks,respectively;③Valsartan groups:VAS1 (n=10) and VAS 4 (n=10). Valsartan of the dosage of 10 mg•kg^-1•d^-1 and 1.5 mL saline were poured into stomach of rats with AMI for 1 week and 4 weeks(once a day),respectively. The ratio of collagen type Ⅰ to Ⅲ in non-infarction myocardium in left ventricle was detected by immunohistochemical method. The levels of Ang Ⅱ, aldosterone (ALD), endothelin (ET), thromboxane A₂ (TXA₂), and prostacyclin I₂ (PGI₂) in plasma were measured by radioimmunoassay. Results ①The ratio of collagen type Ⅰ to Ⅲ in non-infarction myocardium in left ventricular was decreased;②Compared with control groups, valsartan could decrease ALD, ET, and TXA₂ and increase AngⅡ and PGI₂ in plasma. Conclusion Valsartan has beneficial effects on LVRM after MI.

Key words: myocardial infarction, collagen, angiotensin Ⅱ, disease models, animal