关键词: 药物疗法, 脱乙酰壳聚糖, 疾病模型, 动物

Abstract: Objective To study the inhibitory and repairing effects of deacetylchitosan on gastric ulcer in animal models. Methods Wistar rats were used to set up water-binded stress (n=40), acetic acid-cauterizated (n=32),and gastric mucosa trauma (n=32) models. The rat models were randomly divided into control group (0.5% CMC 10 mL•kg^-1) and experimental groups (Deacetylchitosan Ⅰ： 100 g•L^-1•kg^-1;Deacetylchitosan Ⅱ:50 g•L^-1•kg^-1;Ranitidine:3 g•L^-1•kg^-1). The ulcer indexes and ulcer areas were observed.Results The ulcer indexes in water-binded stress ulcer in Deacetylchitosan Ⅰ, Ⅱ groups and Ranitidine group were lower than that in control （P<0.01），there were no significant differences between experimental groups; The ulcer areas in acetic acid-cauterizated and gastric mucosa trauma ulcer in Deacetylchitosan Ⅰ，Ⅱ groups and Ranitidine group were lower than that in control（P<0.01）, there were no significant differences between experimental groups. Conclusion Deacetylchitosan has inhibitory effects on water-binded stress and acetic acid-cauterizated ulcer, and has repairing effect on gastric mucosa trauma ulcer.

Key words: drug therapy, deacetylchitosan, disease models, animal