关键词: 脑缺血, 血液粘度, 血小板粘附, 血小板聚集, 血栓弹力描记术

Abstract: Objective To observe the effects of Shexiang Anti-thrombosis Pill (SATP) on platelet function and blood viscosity in experimental cerebral ischemia rats. Methods The cerebral ischemia model induced by bilateral common carotid artery clamping and controlled hemorrhage to a mean arterial pressure of 50 mmHg was established in rats treated by continuous intragastric administration of SATP 1.5,3.0,6.0 g•kg^-1 for 14 days. The effects of SATP on the blood viscosity (ηB), plasma viscosity (ηP), platelet aggregation and adhesion functions and thrombus stretch picture were measured after 15 minutes. Results SATP 3.0 g•kg^-1 and 6.0 g•kg^-1 decreased the ηB and ηP markedly,and inhibited platelet aggregation and adhesion functions,but had not significant effect on thrombus stretch picture. Conclusion SATP can protect the cerebral tissue from ischemia injury by decreasing the ηB and ηP and platelet aggregation and adhesion functions. After the conversion of honey pill into water pill, the pharmacological effect of SATP is increased significantly.

Key words: brain ischemia, blood viscosity, platelet adhesiveness, platelet aggregation, thrombelastography