关键词: CEA, 乳腺肿瘤

Abstract: Abstract:Objective To evaluate the application values of time-resolves fluroimmunoassay (TRFIA) technique for CA15-3 and CEA detection in mammary gland diseases.Methods TRFIA was used to detect the serum concentrations of CA15-3 and CEA in normal control group (n=57),hyperplasia group (n=206),benign mammary neoplasm group (n=136),mammary cancer with out recurrence or metastasis group (n=89) and mammary cancer with recurrence or metastasis group (n=39).Results There were no significant differences of CA15-3 and CEA serum concentrations between control group,mammary hyperplasia group and benign mammary neoplasm group (P>0.05).However,the CA15-3 and CEA concentrations in mammary cancer without recurrence or metastasis group were significantly higher than those in the former three groups (P<0.05).Also,the CA15-3 and CEA concentrations in mammary cancer with recurrence or metastasis group were remarkably higher than those in the former three groups(Ｐ<0.01) and mammary cancer without recurrence or metastasis group (Ｐ<0.05).While CA15-3 and CEA concentrations in the 3-month post-operation group showed no significant difference with those in the former three groups(Ｐ>0.05),though,were distinctly lower than those in the mammary cancer without or with recurrence or metastasis groups (P<0.05,Ｐ<0.01).Conclusion The atraumatic detection of CA15-3 and CEA may be used as indexes in diagnosis,therapy，and curative effect estimation post-operation and following-up observation for mammary diseases.

Key words: CEA, breast neoplasms