关键词: 糖尿病, 药物疗法, 抗氧化剂

Abstract: Objective To observe the effect of enzymes-hydrolyzed wheat bran (EHWB) on antioxidant system in diabetic rats.Methods Diabetes mellitus models were induced by alloxan inject ion and EHWB was used to test its effect on anti-oxidative capacity; the EHWB was given intragastrically (i.g.), sodium ferulate (SF) as a positive group. The level of blood glucose, total anti-oxidative capacity (T-AOC), the activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and xanthine oxidase (XOD), and the content of malondiadehyde (MDA) were detected respectivel y in serum and liver of rats. Results EHWB significantly decreased the level of blood glucose and increased the level of T-AOC, as well as the activities of GSH-Px and SOD , and decreased the activity of XOD and the content of MDA. However, there was no difference between the groups feeding SF and EHWB. Conclusion EHWB can be used to decrease blood glucose and improve antioxidant ability in diabetes mellitus rats，the effect of EHWB is similar to SF. The effect of decreasing blood glucose of EHWB is related to protecting liver.

Key words: diabetes mellitus, dr ug therapy, antioxidants