吉林大学学报(医学版) ›› 2016, Vol. 42 ›› Issue (04): 803-806.doi: 10.13481/j.1671-587x.20160432

• 临床医学 • 上一篇    下一篇

红蓝光照射联合西黄胶囊治疗面部中重度痤疮疗效及安全性评价

李劲然1, 王连有2, 王震1, 孙铭徽1, 朱明姬1, 贾玉玺1   

  1. 1. 吉林大学中日联谊医院皮肤科, 吉林 长春 130033;
    2. 吉林大学中日联谊医院病理科, 吉林 长春 130033
  • 收稿日期:2016-04-19 发布日期:2016-07-20
  • 通讯作者: 朱明姬,教授,硕士研究生导师(Tel:0431-84995523,E-mail:zhumingji33@163.com);贾玉玺,主治医师(Tel:0431-84995523,E-mail:jiayuxi2006@126.com) E-mail:zhumingji33@163.com;jiayuxi2006@126.com
  • 作者简介:李劲然(1991-),男,吉林省长春市人,在读医学硕士,主要从事皮肤病的基础与临床方面的研究。
  • 基金资助:

    吉林省科技厅社会发展处基金资助课题(20090471)

Evaluation on curative efficacy and safety of red-blue light irradiation combined with Xihuang Capsules in treatment of moderate to severe acne vulgaris

LI Jinran1, WANG Lianyou2, WANG Zhen1, SUN Minghui1, ZHU Mingji1, JIA Yuxi1   

  1. 1. Department of Dermatology, China-Japan Union Hospital, Jilin University, Changchun 130033, China;
    2. Department of Pathology, China-Japan Union Hospital, Changchun 130033, China
  • Received:2016-04-19 Published:2016-07-20

摘要:

目的:采用红蓝光照射联合西黄胶囊治疗面部中重度痤疮,并评价其疗效及安全性。方法:80例中重度痤疮患者随机分为西黄胶囊组(对照组)和红蓝光照射联合西黄胶囊组(观察组),每组40例。对照组患者口服西黄胶囊,每次1.5g,每日2次;观察组患者采用红蓝光照射治疗,每次20min,每周2次,同时口服西黄胶囊,每次1.5g,每日2次;治疗时间均为4周。治疗后2和4周各随访1次,观察患者皮损变化情况及不良反应发生情况,比较其疗效。结果:治疗2周后,观察组总有效率为67.5%,对照组为52.5%,2组总有效率比较差异无统计学意义(P > 0.05),但观察组患者炎性皮损和非炎性皮损消退数目明显多于对照组(P=0.002和P=0.005);治疗4周后,观察组总有效率为85.0%,对照组总有效率为65.0%,观察组疗效明显优于对照组(P < 0.05),且观察组患者炎性皮损和非炎性皮损消退数目均明显多于对照组(P=0.01和 P=0.001)。治疗期间2组患者均未见严重不良反应,观察组仅有2例患者在红光照射治疗后有轻度头痛及恶心症状,下调照射剂量后症状消失。结论:红蓝光照射联合西黄胶囊治疗面部中重度痤疮具有见效快、疗效好、安全性高的优势,值得在临床上推广应用。

关键词: 红蓝光, 西黄胶囊, 痤疮, 寻常, 疗效

Abstract:

Objective: To evaluate the clinical therapeutic efficacy and safety of red-blue light irradiation combined with Xihuang Capsules in the treatment of moderate to severe acne vulgaris. Methods: Eighty patients with moderate to severe acne vulgaris were randomly divided into Xihuang Capsules group (control group) and red-blue light irradiation combined with Xihuang Capsules group(observation group). The patients in observation group were treated with red-blue light irradiation (20 min biw,4 weeks)combined with Xihuang Capsules (1.5 g bid,4 weeks), while the patients in control group took only Xihuang Capsules orally (1.5 g bid, 4 weeks), The changes of skin lesions and adverse reactions were observed and the curative efficacies were compared at 2 or 4 weeks after treatment. Results: After 2- week- treatment, the total effective rate in observation group was 67.5% while the total effective rate in control group was 52.5%,there was no statistically significant difference between two groups (P > 0.05). The regression number of inflammatory and non-inflammatory skin lesions in observation group was significantly higher than that in control group (P < 0.05). After 4- week- treatment, the total effective rate in observation group was significantly higher than that in control group (85.0% vs 65.0% ),and the difference was statistically significant (P < 0.05);the regression number of inflammatory and non-inflammatory skin lesions in observation group was significantly higher than that in control group (P < 0.05).During the treatment, there were no severe adverse reactions in two groups. Mild headache and nausea occurred in observation group after red-blue light irradiation, but the above symptoms disappeared after reducing the irradiation dose. Conclusion: Red-blue light irradiation combined with Xihuang Capsules in the treatment of moderate to severe acne is proved to be a significantly effective and safe method,and it is worth to be promoted in clinic.

Key words: red -blue light, Xihuang Capsules, acne vulgaris, curative efficacy

中图分类号: 

  • R758.733