乳腺癌组织中信号传导和转录激活因子1的表达及其与预后的关系

doi:10.13481/j.1671-587x.20150527

摘要/Abstract

摘要：

目的:探讨乳腺良、恶性肿瘤组织中信号传导和转录激活因子1(STAT1)的表达,阐明其表达与乳腺癌预后的关系。方法:采用免疫组织化学法检测87例乳腺癌患者的和37例良性乳腺肿瘤患者肿瘤组织中STAT1的表达情况,分析其表达与患者不同临床参数和预后的关系。采用Kaplan-Merier法进行生存分析,绘制生存曲线,采用Log-rank检验比较生存曲线的差异。采用COX比例风险回归模型进行单因素和多因素分析。结果:乳腺癌组织中STAT1强阳性率小于乳腺良性肿瘤组织(P<0.01)。孕激素受体(PR)阳性乳腺癌患者的STAT1强阳性表达率高于PR阴性患者(P<0.05)。STAT1强阳性表达患者的总生存期(OS)长于弱阳性表达者(P=0.044);而STAT1强阳性表达患者的无病生存期(DFS)长于弱阳性表达者,但组间比较差异无统计学意义(P=0.071)。单因素分析,是否行术后内分泌治疗、STAT1表达状态、激素受体状态、Her-2表达状态是影响患者OS的因素;TNM分期、是否行术后内分泌治疗、激素受体状态、Her-2表达状态是影响患者DFS的因素。多因素分析,是否行术后内分泌治疗和PR表达状态为影响患者OS的独立预后因素;TNM分期、是否行术后内分泌治疗和PR表达状态、Her-2表达状态为影响患者DFS的独立预后因素。结论:STAT1在PR阳性的乳腺癌组织中表达率高,STAT1的表达情况对患者的预后具有积极的影响。

关键词: 乳腺肿瘤, 信号传导和转录激活因子1, 孕激素受体, 预后

Abstract:

Objective To explore the expression of signal transducers and activators of transcription 1(STAT1) in breast cancer tissue,and to investigate the relationship between the expression of STAT1 and prognosis of breast cancer. Methods The expressions of STAT1 in tumor tissue of 37 cases of benign breast tumor and 87 cases of breast cancer patients were detected by immunohistochemical technique.The associations between the expression of STAT1 and clinical parameters and prognosis were analyzed.Kaplan-Merier analysis and Log-rank test were used to conduct the overall survival(OS) analysis and draw the survival curve and detect the differences between survival curves. Results The strongly positive expression rate of STAT1 in breast cancer tissue was lower than that in benign tissue(P<0.01).The breast cancer patients with positive progesterone receptor(PR) had a higher expression of STAT1 compared with the breast cancer patients with negtive PR (P<0.05).The OS of the patients with high expression of STAT1 was longer than that of the patients with low expression of STAT1(P=0.044);the disease-free survival (DFS) of the patients with strongly positive expression of STAT1 was longer than that of the patients with lowly positive expression of STAT1,but there was no significant difference between them(P=0.071).The single factor analysis results showed that the endocrine therapy or not,expression of STAT1,hormone receptor status,and Her-2 expression were the influencing factors of OS;the TNM stage,endocrine therapy or not,hormone receptor status,and Her-2 expression were the influencing factors of DFS.The multifactor analysis results demonstrated that the endocrine therapy or not and expression of PR were the independent factors influencing OS;the TNM stage,endocrine therapy or not,expression of PR,and Her-2 expression were the independent factors influencing DFS. Conclusion The expression of STAT1 is higher in the breast cancer tissue with positive PR,and the expression of STAT1 may have a positive influence in the prognosis of breast cancer.

Key words: breast neoplasms, signal transducers and activators of transcription 1, progesterone receptor, prognosis

中图分类号:

R737.9

刘雨欣, 吴迪, 付彤, 赵刚, 付京, 宋东. 乳腺癌组织中信号传导和转录激活因子1的表达及其与预后的关系[J]. 吉林大学学报(医学版), 2015, 41(05): 1012-1017.

LIU Yuxin, WU Di, FU Tong, ZHAO Gang, FU Jing, SONG Dong. Expression of signal transducers and activators of transcription 1 in breast cancer tissue and its relationship with prognosis[J]. Journal of Jilin University Medicine Edition, 2015, 41(05): 1012-1017.

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