关键词: 学习记忆, 寰枢椎关节, 动物, 实验

Abstract: Objective To observe the changes of learning and memory abilities induced by cumulative lactic acid for long time in atlas dentata vertebrae in mice. Methods 30% lactic acid was injected into the place between the first and the second cervical vertebrae. The changes of lesarning and memory in mice were observed with step-down avoidance test,water-maze test and hole-board test. The organ index of the brain was calculated and the pathological changes were observed. Results In step-down avoidance test, the reaction period prolonged and wrong times increased obviously(P<0.01), and the latency period shortened significantly. The whole-distance swimming time prolonged and mistakes increased in water-maze test(P<0.01). In hole-board test, the latency period prolonged and the times of extending the holes decreased significantly(P<0.01). The organ index of model mice decreased significantly(P<0.01), and pathological changes such as the collo id corpuscle, necrotic cells increasing, inflammation cells infiltrating in blood vessels were discovered. Conclusion The abilities of learning and memory of the model mice are hurtsignificantly by accumulation of lacticacid in cervical part.

Key words: learning and memory, atlanto-axial joint, animals, laboratory