关键词: 角膜移植,新生血管化, 病理性,氧化还原酶类/拮抗剂和抑制剂

Abstract: Objective To study the inhibitory effects of cyclooxygenase-2-selective inhibitor on angiogenesis postkeratoplasty. Methods The rat keratoplasty models between SD and Wistar rats were made. All the rats were taken orally cyclooxygenase-1-selective inhibitor,cyclooxygenase-2-selective inhibitor，non selective-cyclooxygenase inhibitor, and physiological saline separately. The rejection values (RV) according to edema,opacity and new vessel of the cornea graft were measured. The new vessel response area was calculated by observing the new vessel of cornea. Results The RV values of cyclooxygenase-1-selective inhibitor and control groups were more than 5 at the 7 day after operation. Rejection had been found in these two groups while it hadn′t in other two groups. The new vessel of cyclooxygenase-2-selective inhibitor group and cyclooxygenase-1-selective inhibitor group at the 7 day could be detected by slit lamp on the cornea bed. The new vessel of other groups approached the cornea graft. The pathological section examination had the same conclusion. The value of RV and the new vessel response area of the groups in which the rats took cyclooxygenase-2-selective inhibitor and non selective-cyclooxygenase inhibitor were less than those of other groups. Conclusion Cyclooxygenase-2-selective inhibitor can inhibit angiogenesis postkeratoplasty.

Key words: corned transplantation, keratoplasty,neovascularization, pathologic,oxidoreductases/antagonists & inhibitors