关键词: 环氧化酶-2, 乳腺肿瘤, 腋窝淋巴结

Abstract: Objective To detect COX-2 expressions in primary tumor and axillary lymph node tissues of breast cancer, and to study the relationship between COX-2 expression in breast cancer and lymph node metastasis. Methods The expressions of COX-2 in 9 normal breast tissues, 50 primary breast cancer tissues, 19 positive axillary lymph nodes and 31 negative axillary lymph nodes were detected with immunohistochemistry S-P method. Results COX-2 staining was granular and localized to the cytoplasm of tumor cells. In normal breast tissues, COX-2 staining was granular and localized to mesenchymocyte. In negative lymph nodes, COX-2 staining was granular and localized to macrophagus cytoplasm. The positive expression rates of COX-2 in normal breast tissues, primary breast cancer tissues, positive axillary lymph nodes and negative axillary lymph nodes were 11.1%, 60.0%, 84.2%, and 32.3%, respectively. There were significant differences of COX-2 positive expression rates between normal breast tissues, primary breast cancer tissues and positive axillary lymph nodes (P<0.01). There was significantly difference of COX-2 positive expression rate between positive-lymph node primary breast cancer tissues and negative-lymph node primary breast cancer tissues (P<0.01), and also between positive axillary lymph node tissues and negative axillary lymph node tissues (P<0.001). Conclusion The patients with COX-2 positive expression possibly have axillary lymph node metastases of breast cancer.

Key words: cyclooxygenase-2, breast neoplasms, axillary lymph node metastases