关键词: 铜, 痕量元素, 拮抗作用, 动物, 实验

Abstract: Objective To observe the distribution and change regularity of molybdenum (Mo) and copper (Cu) in blood and tissues in rabbits fed on supplement with different levels of Mo，and to study the biological antagonism of Mo on Cu.Methods Fifty rabbits were divided into five groups：control group and four experimental groups （treated with different doses of Mo）. The experimental time was four months. The contents of Mo and Cu in tissues of the rabbits were determined. Results Both Mo and Cu contents were increased in blood，liver，kidney，lung，spleen，pancreas，myocardium and muscle of rabbits with the increase of Mo intake in the diet（P<0.01）. The contents of Mo and Cu in kidney were increased remarkably, and closely related to Mo intake (r=0.9995,r=0.9997). The contents of Mo in bone, cartilage and hair were also increased （P<0.01）, but not Cu when compared with control group. Conclusion The antagonism of Mo on Cu may be formed. Because Mo and Cu may be related to the stable Mo-Cu-protein complex without biological activity in blood or tissues. The complex heaping in blood or tissues can not be taken good advantage by the organism so that the animals show symptom of cooper-deficiency.

Key words: copper, trace elements, antagonism, animals, laboratory