吉林大学学报(医学版)

• 基础研究 • 上一篇    下一篇

18F-FDG PET-CT在非小细胞肺癌TNM分期中的应用及其临床意义

左晓军,倪冠英   

  1. 吉林省肿瘤医院PET-CT核医学科,吉林 长春 130012
  • 收稿日期:2014-05-26 出版日期:2014-11-28 发布日期:2015-01-18
  • 通讯作者: 左晓军(Tel:0431-85872689,E-mail:zuo_xiaojun@163.com) E-mail:zuo_xiaojun@163.com
  • 作者简介:左晓军(1959-),男,吉林省长春市人,主任医师,主要从事PET/CT在肿瘤诊断应用方面的研究。
  • 基金资助:

     国家自然科学基金资助课题(30970682)

Application of 18F-FDG PET-CT in TNM staging of
non-small cell lung cancer and clinical significance

ZUO Xiao-jun,NI Guan-ying    

  1. Department of PET-CT and Neclear Medcine,Jilin Tumor Hospital,Changchun 130012,China
  • Received:2014-05-26 Online:2014-11-28 Published:2015-01-18

摘要:

目的:比较18F-FDG PET-CT显像、CT检测和金标准检测方法对非小细胞肺癌(NSCLC)TNM分期的诊断结果,探讨 18F-FDG PET-CT显像在NSCLC TNM分期中的临床价值。方法:对65例确诊的行全身18F-FDG PET-CT显像的NSCLC患者通过盲法阅片进行TNM分期诊断;采用灵敏度(Se)、特异度(Sp)、阳性预测值(PPV)、阴性预测值(NPV)、符合率和Kappa分析评价PET-CT和CT 2种诊断方法在NSCLC患者TNM分期中的诊断价值。结果:与金标准比较,CT和PET
-CT对65例NSCLC患者T分期诊断结果分别为符合率=72.31%,Kappa=0.46;符合率=78.46%,Kappa=0.60;对58例患者N分期诊断结果分别为符合率= 74.14%,Kappa=0.50;符合率=87.94%,Kappa=0.78;CT和PET-CT诊断淋巴结转移的结果分别为Se=64.04%,Sp=77.53%,P
PV=85.07%,NPV=51.88%,符合率=68.54%,Kappa=0.37;Se=91.01%,Sp=83.15%,PPV=91.53%,NPV=82.22%,符合率=88.39%,Kappa=0.74;PET-CT对NSCLC远处转移的总体患者检出率和转移灶检出量均高于CT。结论:18F-FDG PET-CT在诊断NSCLC患者TNM分期中具有较
高的价值。

关键词: 癌, 非小细胞肺;肿瘤分期;正电子发射型体层摄影术;X 线计算机体层摄影

Abstract:

Objective To compare the diagnostic results of 18F-deoxyglucose positron emission tomographic-computed tomographic (18F-FDG PET-CT) imaging ,CT and golden standards in TNM stating of non-small cell lung cancer (NSCLC),and  to  evaluate the diagnostic value of 18F-FDG PET-CT imaging in TNM staging of NSCLC.Methods 18F-FDG PET-CT was performed in the 65 patients with NSCLC who were diagnosed by pathology.Blind interpretation was used to dignose the TNM staging.The sensitivity(Se),specificity(Sp),positive predict value(PPV) and negative predict value(NPV),coincidence rate and Kappa analysis were performed to evaluate the values of PET-CT and CT in diagnosing TNM staging of NSCLC.Results Compared with golden standard,the di
agnostic results of T staging among 65 NSCLC patients by CT and PET-CT were respectively as coincidence rate=72.31%,Kappa=0.46;coincidence rate=78.46%,Kappa=0.60;the diagnostic results of N staging among 58 NSCLC patients by CT and PET-CT were respectively as coincidence rate=74.14%,Kappa=0.50;coincidence rate = 87.94%,Kappa=0.78;the diagnostic results of lymph node metastasis by CT and PET-CT were respectively as Se=64.04%,Sp=77.53%,PPV=85.07%,NPV=51.88%,coincidence rate =68.54%,Kappa=0.37;Se=91.01%,Sp=83.15%,PPV=91.53%,NPV=82.22%,coincidence rate =88.39%,Kappa=0.74;the total detection rate and amount of metastasis by PET-CT were significantly higher than that by CT.Conclusion 18F-FDGPET-CT  has significant value on the diagnosis of  the TNM staging of NSCLC.

Key words: carcinoma, non-small cell lung , neoplasm staging, PET-CT, X-ray computerized tomography

中图分类号: 

  • R734.2