Journal of Jilin University(Medicine Edition) ›› 2021, Vol. 47 ›› Issue (4): 965-970.doi: 10.13481/j.1671-587X.20210420
• Research in basic medicine • Previous Articles Next Articles
Zhenhui MA1,2,shulian LYU3,Yaping TIAN1()
Received:
2021-02-02
Online:
2021-07-28
Published:
2021-07-22
Contact:
Yaping TIAN
E-mail:typ@jlu.edu.cn
CLC Number:
Zhenhui MA,shulian LYU,Yaping TIAN. Effects of Bozhi glycopeptide on proliferation and adhesion function of human keratinocytes and its mechanism in treatment of psoriasis[J].Journal of Jilin University(Medicine Edition), 2021, 47(4): 965-970.
Tab.3
Proliferation rates of HaCaT cells in various groups after treated for different time"
Group | Proliferation rate | |
---|---|---|
(t/h) 24 | 48 | |
Control | 100.00±0.22 | 100.00±0.19 |
Bozhi glycopeptide(mg?L-1) | ||
0.625 | 93.81±0.06 | 96.71±0.17 |
1.250 | 90.58±0.12** 90.01±0.22** | 84.48±0.24* |
2.500 | 85.67±0.21* | |
5.000 | 87.83±0.19** | 90.15±0.19 |
10.000 | 85.61±0.33** | 82.69±0.37* |
20.000 | 87.44±0.17** | 77.01±0.26** |
40.000 | 88.82±0.25** | 91.34±0.41 |
80.000 | 85.64±0.29** | 91.04±0.25 |
1 | 郑 雯, 李刚刚, 刘清民, 等. 复方青黛胶囊对银屑病微环境下HaCaT细胞分泌细胞因子的影响[J].中国皮肤性病学杂志, 2021, 35(3): 261-265. |
2 | MICHALEK I M, LORING B, JOHN S M. A systematic review of worldwide epidemiology of psoriasis[J]. J Eur Acad Dermatol Venereol, 2017,31(2):205-212. |
3 | 李若花, 陈冬琼, 欧柏生, 等.银屑病病因病机及治疗进展[J]. 湖南中医杂志, 2019, 35(3): 160-163. |
4 | RICH P, SIGURGEIRSSON B, THACI D, et al. Secukinumab induction and maintenance therapy in moderate-to-severe plaque psoriasis: a randomized, double-blind, placebo-controlled, phase Ⅱ regimen-finding study[J]. Br J Dermatol,2013,168(2): 402-411. |
5 | 李慧贤,胡丽,郑 焱,等.基于全球疾病负担(GBD)大数据的中国银屑病流行病学负担分析[J/OL].中国皮肤性病学杂志[2021-03-06].. |
6 | MYLONAS A, CONRAD C. Psoriasis: classical vs.paradoxical.The Yin-yang of TNF and type Ⅰinterferon[J]. Front Immunol, 2018, 9: 2746. |
7 | BAI F, ZHENG W, DONG Y, et al. Serum levels of adipokines and cytokines in psoriasis patients: a systematic review and meta-analysis[J]. Oncotarget, 2018, 9(1): 1266-1278. |
8 | KHANDPUR S, GUPTA V, DAYASAGAR DAS D, et al. Is there a correlation of serum and tissue T helper-1 and -2 cytokine profiles with psoriasis activity and severity? A cross-sectional study[J]. Indian J Dermatol Venereol Leprol, 2018, 84(4): 414-418. |
9 | LOWES M A, SUÁREZ-FARIÑAS M, KRUEGER J G. Immunology of psoriasis[J]. Annu Rev Immunol, 2014, 32: 227-255. |
10 | CHIRICOZZI A, ROMANELLI P, VOLPE E, et al. Scanning the immunopathogenesis of psoriasis[J]. Int J Mol Sci, 2018, 19(1): E179. |
11 | 曾秋红, 郝平生. 中医调节Th1/Th2平衡治疗寻常型银屑病研究进展[J].亚太传统医药,2021,17(1):158-161. |
12 | WIESE KE, NUSSE R, RVAN AMERONGEN. Wnt signalling: conquering complexity[J]. Development, 2018, 145(12): 456-461. |
13 | KIMELMAN D, XU W.β-catenin destruction complex: insights and questions from a structural perspective[J]. Oncogene, 2006, 25(57): 7482-7491. |
14 | 果 嘉. 薄芝糖肽注射液治疗肺癌的有效性分析[J]. 中国现代药物应用, 2020, 14(8): 149-150. |
15 | 王应权. 薄芝糖肽注射液治疗大面积寻常型银屑病的临床疗效及安全性评价[J]. 河北医学, 2017, 23(12): 1994-1997. |
16 | 王思扬, 李 青. 薄芝糖肽临床应用中文文献分析[J]. 中国药师, 2016, 19(6): 1174-1179. |
17 | 关 鹏. 薄芝糖肽注射液联合阿维A胶囊对寻常型银屑病患者血清VEGF、sE-slelctin水平的影响[J]. 医药论坛杂志, 2019, 40(2): 165-167. |
18 | KHATER M H, ABDALLAALHABIB S, ELKSHISHY K A, et al. Evaluation of Galectin3 levels in psoriatic patients treated by narrow-band UVB phototherapy[J]. J Dermatolog Treat, 2020, 31(8): 758-762. |
19 | LIN C M, YUAN Y P, CHEN X C, et al. Expression of Wnt/β-catenin signaling, stem-cell markers and proliferating cell markers in rat whisker hair follicles[J]. J Mol Histol, 2015, 46(3): 233-240. |
20 | RAO A S, KREMENEVSKAJA N, RVON WASIELEWSKI, et al. Wnt/beta-catenin signaling mediates antineoplastic effects of imatinib mesylate (gleevec) in anaplastic thyroid cancer[J]. J Clin Endocrinol Metab, 2006, 91(1): 159-168. |
21 | FATHKE C, WILSON L, SHAH K, et al. Wnt signaling induces epithelial differentiation during cutaneous wound healing[J]. BMC Cell Biol, 2006, 7: 4. |
22 | 孙 钰. 薄芝糖肽抑制人角质形成细胞增殖及其抗银屑病作用的初步研究[D].长春:吉林大学, 2014. |
23 | HAMPTON P J, ROSS O K, REYNOLDS N J. Increased nuclear beta-catenin in suprabasal involved psoriatic epidermis[J]. Br J Dermatol, 2007, 157(6): 1168-1177. |
24 | 龙剑文, 皮先明, 涂亚庭. 进行期寻常性银屑病皮损β-连环蛋白、VEGF和VEGFR-2的mRNA表达[J]. 中国皮肤性病学杂志, 2015, 29(1): 29-31. |
25 | XUE Y, LIU Y, BIAN X, et al. miR-205-5p inhibits psoriasis-associated proliferation and angiogenesis: Wnt/β-catenin and mitogen-activated protein kinase signaling pathway are involved[J].J Dermatol,2020,47(8):882-892. |
26 | LIU S G, LUO G P, QU Y B, et al. Indirubin inhibits Wnt/β-catenin signal pathway via promoter demethylation of WIF-1[J]. BMC Complement Med Ther,2020,20(1):250. |
27 | GUPTA G, SINGH Y, TIWARI J, et al. Beta-catenin non-canonical pathway: a potential target for inflammatory and hyperproliferative state via expression of transglutaminase 2 in psoriatic skin keratinocyte[J]. Dermatol Ther, 2020, 33(6): e14209. |
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