Journal of Jilin University(Medicine Edition) ›› 2023, Vol. 49 ›› Issue (2): 520-526.doi: 10.13481/j.1671-587X.20230230
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Received:
2022-02-15
Online:
2023-03-28
Published:
2023-04-24
CLC Number:
Tab. 1
Related signaling pathways of bone metabolism regulated by SrR"
Signaling pathway | Therapeutic target | Cell | Effect | |
---|---|---|---|---|
TGF-β/Smad[ | Smad↑ | Osteoblasts | Promote bone formation | |
Hh[ | Gli1↑ PPARγ↓ | BMSCs | Promote bone formation Reduce lipid formation | |
Wnt/β-catenin[ | Wnt signaling pathway related molecules↑ PPARγ↓ Sclerostin↓ | Osteoblasts BMSCs | Promote bone formation Reduce lipid formation | |
MAPK[ | Setd2↑ CaSR↑ | Osteoblasts Dental pulp stem cells | Promote bone formation | |
PI3K/Akt[ | CaSR↑ PI3K↑ | BMSCs | Promote bone formation | |
RhoA-ROCK[ | ROCK1↑ | BMSCs | Promote bone formation | |
NF-κB[ | Calcium channel↑ | Vascular smooth muscle cells | Promote bone formation | |
CaN-NFAT[ | NFAT↑ PPARγ↓ | BMSCs | Promote bone formation Reduce lipid formation | |
↑indicated increase;↓indicated decrease. |
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