雷奈酸锶对骨代谢的影响及其机制的研究进展

doi:10.13481/j.1671-587X.20230230

Abstract

CLC Number:

R965

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References 67

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Signaling pathway	Therapeutic target	Cell	Effect
TGF-β/Smad^[24-25]	Smad↑	Osteoblasts	Promote bone formation
Hh^[29-30]	Gli1↑ PPARγ↓	BMSCs	Promote bone formation Reduce lipid formation
Wnt/β-catenin^[31-35]	Wnt signaling pathway related molecules↑ PPARγ↓ Sclerostin↓	Osteoblasts BMSCs	Promote bone formation Reduce lipid formation
MAPK^[39-42]	Setd2↑ CaSR↑	Osteoblasts Dental pulp stem cells	Promote bone formation
PI3K/Akt^[40,43-44]	CaSR↑ PI3K↑	BMSCs	Promote bone formation
RhoA-ROCK^[45-46]	ROCK1↑	BMSCs	Promote bone formation
NF-κB^[47]	Calcium channel↑	Vascular smooth muscle cells	Promote bone formation
CaN-NFAT^[32,49]	NFAT↑ PPARγ↓	BMSCs	Promote bone formation Reduce lipid formation
↑indicated increase；↓indicated decrease.

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Research progress in effect of strontium ranelate on bone metabolism and its mechanism

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