巨噬细胞极化与口腔疾病关系的研究进展

doi:10.13481/j.1671-587X.20240334

Abstract

Abstract:

The macrophages， as a crucial component of the body’s immune system， can be polarized into M1 and M2 types by different cellular molecules in various environments， and contribute to the progression of various diseases. In inflammatory responses， the M1 macrophages are primarily regarded as the pro-inflammatory cells， facilitate the inflammation progression， tissue destruction， and bone resorption， while M2 macrophages， as inflammatory cells， participate in tissue healing and bone repairment. In the tumor microenvironment， the roles of M1 and M2 macrophages are reversed. The periodontitis， pulpitis， and oral squamous cell carcinoma （OSCC） are the most prevalent inflammation and tumor in the oral cavity. Therefore， this article summarizes the relevant researches from home and abroad on the polarization of macrophages in oral inflammatory responses such as periodontitis， peri-implantitis， and pulpitis， bone remodeling during orthodontic treatment， and OSCC， and elucidate the metabolic activities of macrophages in infiammation，tumor，and bone remodeling and the mechanism of regulating the onset and development of diseases by the macrophage polarization， and provides new perspectives for the clinical treatment.

Key words: Macrophage polarization, Inflammation, Oral squamous cell carcinoma, Bone remodel, Periodontitis

CLC Number:

Yiyan YU,Zhimin ZHANG,Jiawen CHEN,Xin LIU,Yan LI,Hongyan ZHAO. Research progress in relationship between macrophage polarization and oral diseases[J].Journal of Jilin University(Medicine Edition), 2024, 50(3): 864-871.

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Research progress in relationship between macrophage polarization and oral diseases

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