Journal of Jilin University(Medicine Edition) ›› 2024, Vol. 50 ›› Issue (6): 1773-1779.doi: 10.13481/j.1671-587X.20240633

• Review • Previous Articles    

Research progress in biological characteristics of dental pulp stem cells and their applications in treatment of corneal and retinal diseases

Xiangyu LIU1,Mengdi ZHANG1,Jixue WANG2,Chunling XU1()   

  1. 1.Department of Ophthalmology,Second Hospital,Jilin University,Changchun 130041,China
    2.Department of Optometry,Baicheng Medical College,Baicheng 137000,China
  • Received:2023-06-05 Online:2024-11-28 Published:2024-12-10
  • Contact: Chunling XU E-mail:xucl@jlu.edu.cn

Abstract:

Dental pulp stem cells (DPSCs) are a type of mesenchymal stem cells with broad application potential. Due to their multipotent differentiation capabilities and ease of access, DPSCs have become a focus of research in the field of ophthalmology. In recent years, DPSCs have shown the potential clinical applications in the treatment of corneal epithelial injuries and retinal degenerative diseases. DPSCs can promote the corneal epithelial regeneration and reconstruction by differentiating into the corneal epithelial cells and inhibiting the M1 macrophages. Additionally, DPSCs can differentiate into the retinal photoreceptor-like cells and retinal ganglion-like cells, replace original retinal neurons, secrete neurotrophic factors to mediate injury repair, promote retinal regeneration, and improve the original function of the retina. This article systematically reviews the relevant domestic and international literatures in recent years, discussing the biological characteristics of DPSCs and the research progress in their applieation in the treatment of corneal and retinal diseases, with the aim of providing insights and strategies for the study of DPSCs in translational medicine and ophthalmic-related diseases.KEYWOEDS Dental pulp stem cells; Eye; Cornea; Retina; Paracrine

CLC Number: 

  • R774.1