去泛素化酶OTUB2与肿瘤发生发展关系的研究进展

doi:10.13481/j.1671-587X.20250634

Abstract

Abstract:

Deubiquitinating enzymes are important hydrolases in the protein ubiquitin system， which regulate the dynamic balance of protein ubiquitination and deubiquitination by reversing ubiquitination， and play important roles in biological processes such as regulating protein stability， cell signal transduction， and cell apoptosis. As a member of the deubiquitinating enzyme family， ovarian tumor domain-containing protease （OTU） domain ubiquitin aldehyde binding 2 （OTUB2） can play a key role in DNA damage， signal transduction， cell metabolism， and tumorigenesis by regulating the ubiquitination levels of various substrates. OTUB2 can be abnormally expressed in various cancers， and as a regulatory factor， it significantly affects the growth， development， proliferation， migration， and invasion of cancer cells， and is closely related to the prognosis of the patients， potentially becoming a novel cancer therapeutic target and prognostic biomarker. Currently， there are many studies on the molecular mechanisms of OTUB2， but there are few review reports focusing on its role in cancer. Based on the research results about OTUB2 at home and abroad， this article reviewed the biological function of OTUB2， related signaling pathways， and its latest progress in cancer research， analyzed the application of OTUB2 in cancer treatment and prognosis evaluation， and provided new ideas for future research on OTUB2.

Key words: Deubiquitinating enzyme, OTUB2, Signal transduction, Tumor, Signal pathway

CLC Number:

R262

Hongfei WANG,Guangquan LI. Research progress in relationship between deubiquitinase OTUB2 and occurrence and development of tumor[J].Journal of Jilin University(Medicine Edition), 2025, 51(6): 1763-1770.

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Research progress in relationship between deubiquitinase OTUB2 and occurrence and development of tumor

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