Journal of Jilin University Medicine Edition

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Risk factors of vascular cognitive impairment among Chinese
population:Meta-analysis

YANG Fang1,LIU Qian-qian2,WANG Li-juan3,GUO Wei-ying4,YAO Yan2   

  1. 1.Center for Health Promotion,First Hospital,Jilin University,Changchun 130021,China;2.Department of Epidemiology and Biostatistics,School of Public Health,Jilin University,Changchun 100021,China;3.Department of Neurology,First Hospital,Jilin University,Changchun 130021,China;4. Department of Endocrinology,Jilin University,Changchun 130021,China
  • Received:2013-08-29 Online:2014-05-28 Published:2014-06-05
  • Supported by:

    杨 芳(1971-),女,吉林省长春市人,副教授,医学博士,主要从事慢性疾病健康促进方面的研究。

Abstract:

Objective To explore the risk factors of vascular cognitive impairment (VCI) among Chinese population,and to clarify the scientific evidences for further prevention and treatment.Methods PubMed,CNKI,CBM,VIP and Wangfang databases (from 2002.1 to 2013.1) were searched to collect case-control studies or cohort studies studying risk factors of VCI among Chinese population.Meta-analysis was performed to calculate combined odds ratio (OR) or mean difference (MD) and its 95% confidence interval (95%CI).Results A total of 42 proper papers involving 3 282 cases and 7 815 controls were included in the review.For categorical variables,pooled OR and its 95%CI were as follows:hypertension 2.56(2.03-3.21),hyperlipidemia1.79(1.39-2.30),hyperglycemia 2.46(1.90-3.19),Leukoaraiosis 5.46(2.60-11.46),cerebral infraction multiple foci 4.39(2.61-7.38),stroke history3.79(2.35-6.11),left hemisphere lesions 2.13(1.42-3.20),smoking 1.51(1.08-2.11),drinking 0.99(0.73-1.36),basal ganglia lesions 2.15(1.55-2.99),thalamus lesions 2.34(1.57-3.47);for continuous variables,MD and its 95%CI were as follows:level of TG 0.35(0.15-0.55),level of TC 0.44(-0.16-1.04),level of folic acid -4.10(-5.50- -2.69),vitamin B12  -130.44(-225.46- -35.41). Conclusion Except for drinking and level of TC,hypertension,hyperlipidemia,hyperglycemia,leukoaraiosis,cerebral infraction multiple foci,stroke history,left hemisphere lesions,smoking,basal ganglia lesions,thalamus lesions,high level of TG,low level of folic acid and vitamin B12 might be the risk factors of VCI among Chinese population.

Key words: Chinese population, vascular cognitive impairment, risk factor, Meta-analysis

CLC Number: 

  • R749.1