Abstract: Objective::To investigate the relationship between the expression level of fibrinogen (Fib) and the prognosis of breast cancer patients with Meta-analysis, and to provide evidence-based medical evidence for the judgement of prognosis of the breast cancer patients. Methods:PubMed, EMbase, Cochrane Library and CNKI databases were searched for collecting the studies about the relationship between Fib and prognosis of the breast cancer patients from inception to January 2019. Two reviewers extracted the data according to inclusion and exclusion criteria. Meta-analysis was performed by using Stata 14.0 software. Results:A total of 158 204 patients from 8 case-control studies were included.The heterogeneity test results included in the studies were I²=58.4%,P=0.019, and the data were analyzed using a random effect model. The results suggested that high expression level of Fib was associated with the lower overall survival (OS) in the breast cancer patients(HR=1.37, 95%CI:1.14,1.64, Z=3.36,P=0.001).The high expression level of Fib was associated with the lower OS in the Asia breast cancer patients(HR=1.83, 95%CI:1.23,2.72, Z=3.00,P=0.003).The sensitivity analysis results showed that the results of 8 included studies were stable and reliable; Begg's test, Z=1.61,P=0.108, suggesting that there was no obvious publication bias. Conclusion:High expression level of Fib is significantly associated with the poor prognosis in the breast cancer patients.

Key words: fibrinogen, breast neoplasms, prognosis, Meta-analysis