Abstract:

Objective To investigate the clinical effects of different doses of propranolol in treatment of infantile mixed and deep hemangioma,and to provid theoretical and experimental evidence for  the treatment of hemangioma.Methods The selected 62 patients with  mixed and deep hemangioma were divided randomly into  low dose(1.5mg?kg-1?d-1)　 and high dose(3.0　mg?kg-1?d-1) of propranolol groups,3 times a day,6 months as a course,the changes in hemangioma size and the incidence of adverse reactions  were recorded.Results The efficacy  was evaluated using Achauer system.The total effective rate was 80.65% in low dose of propranolol group and 93.55% in high dose of propranolol group,including  6 cases of class Ⅰ(poor),9 cases of class Ⅱ(moderate),11 cases of classⅢ(good),and 5 cases of class Ⅳ(excellent)in low dose propranolol group；while  2 cases of class Ⅰ(poor),4 cases of class Ⅱ(moderate),10 cases of   class Ⅲ(good) and 15 cases of Ⅳ(excellent)in high dose of propranolol group.The efficacy in  high dose of proprandol group  was significantly better than that in  low dose of proprandol group(P<0.05)，there were no significant differences in the efficacies between different sites and different types(P>0.05) and there was no significant difference in the  incidence of  adverse reaction between  two groups (P>0.05).Conclusion The efficacy of oral 3.0 mg?kg-1?d-1 propranolol in treatment of infantile mixed and deep hemangioma  is  increased significantly,and there is no significant adverse reactions after increasing doses.Therefore,high dose of propranolol should  be recommended in order to improve the therapeutic effect.

Key words: hemangioma, propranolol, therapeutic effect, adverse reaction