低剂量普萘洛尔联合1064nmNd:YAG激光治疗混合型和深层婴儿血管瘤的疗效评价

doi:10.13481/j.1671-587x.20150531

Abstract

Abstract:

Objective To explore the efficacy and safty of low dose propranolol with 1 064 nm Nd:YAG laser on mixed and deeper infantile hemangioma(IH). Methods 60 patients with mixed and deeper IH were randomly divided into propranolol group(n=20,the patients were treated by 1.5 mg·kg-1·d^-1 propranolol),laser group(n=20,the patients were treated by 1 064 nm Nd:YAG laser), and propranolol combined with laser group(n=20,the patients were treated by 1.5 mg·kg^-1·d^-1 propranolol and 1 064 nm Nd:YAG laser).After 6 months,the total efficacy rate, efficacy rate and cure rate,and the scores of adverse event degrees were compared respectively. Results 6 months later,the total efficacy rate,efficacy rate and cure rate of the patients in propranolol combined with laser group were higher than those in laser group and propranolol group(P<0.05);the scores of adverse event degrees in body surface of the patients in propranolol combined with laser group were lower than those in laser group and propranolol group(P<0.05). Conclusion Low dose of propranolol combined with 1 064 nm Nd:YAG laser is effective and safe for the patients with mixed and deeper IH,with the advantages such as better effects,shorter duration and fewer adverse events.

Key words: infantile hemangioma, propranolol, 1 064 nm Nd:YAG laser

CLC Number:

R732.2

ZHONG Shuxia, TAO Yuchun, ZHOU Junfeng, YAO Lei, LIU Yuanyuan, YAN Dongxue, LI Shanshan. Evaluation on efficacy of low dose propranololcombined with 1 064 nm Nd:YAG laser on mixed and deeper infantile hemangioma[J].Journal of Jilin University Medicine Edition, 2015, 41(05): 1032-1035.

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Evaluation on efficacy of low dose propranololcombined with 1 064 nm Nd:YAG laser on mixed and deeper infantile hemangioma

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