有氧运动对肥胖性高血压大鼠肾素-血管紧张素系统和心功能的改善作用

doi:10.13481/j.1671-587x.20150325

Abstract

Abstract:

Objective To observe the influence of aerobic exercise in the renin-angiotensin system (RAS) and cardiac function in the obese hypertension (OH) rats, and to clarify the protective effect of aerobic exercise on OH. Methods The male healthy Sprague-Dawley rats were used to induce rat model of OH by high fat diet.Thirty successfully established OH rats were randomly assigned into sedentary group (OH+S) and exercise group (OH+E) with 15 rats for each group.Meanwhile, 30 rats fed with regular diet were randomly assigned into sedentary group (N+S) and exercise group (N+E) with 15 rats for each group.The rats in OH+E group and N+E group underwent treadmill running at 18 m·min^-1 (60 min each, 5 times a week).Eight weeks later, the systolic blood pressure (SBP), body weight, serum levels of renin, angiotensin Ⅱ and aldosterone of the rats in various groups were measured.Moreover, the obesity related indexes, including triacylglycerol (TG), total cholesterol (TC), Lee's index and fat coefficient (FC), and fat weight were recorded.The PowerLab data system was employed to record the cardiac function, such as left ventricular end diastolic volume (EDV), left ventricular end systolic volume (ESV), fractional shortening (FS) and ejection fraction (EF). Results Compared with OH+S group, the SBP, body weight, serum levels of renin, angiotensin Ⅱ and aldosterone, obesity related indexes and fat content of the rats in OH+E group after exercise were decreased (P<0.05).The FS and EF of the rats in OH+E group were increased and the EDV and ESV were decrased compared with OH+S group (P<0.05).However, the above indexes of the rats inOH+E group were still different from N+S group and N+E group (P<0.05). Conclusion Aerobic exercise can attenuate the RAS activation and improve cardiac function, also improve the symptoms of hypertension and obesity.

Key words: aerobic exercise, obese hypertension, renin-angiotensin system, cardiac function

CLC Number:

R544.1

CHEN Guozhi, ZHANG Jingyu, LIU Fei. Improvement effects of aerobic exercise on renin-angiotensin system and cardiac function in obese hypertensive rats[J].Journal of Jilin University Medicine Edition, 2015, 41(03): 563-567.

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Improvement effects of aerobic exercise on renin-angiotensin system and cardiac function in obese hypertensive rats

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