Abstract: Objective:To assess the changes of myocardial biomechanical parametres of left ventricle of the patients with non-Hodgkin lymphoma(NHL) after anthracycline(ANTH) treatment by using two dimension speckle tracking imaging(2D-STI),and to study the value of 2D-STI in evaluating and monitoring the early cardiac dysfunction of the NHL patients induced by ANTH treatment. Methods:A total of 37 hospital patients who were firstly diagnosed as NHL (ANTH chemotherapy group) and 20 healthy volunteers (normal control group) were selected. The global longitudinal strain(GLS), global radial strain(GRS), global circumferential strain (GCS) and left ventricle twist(LVtw) of the subjects in two groups were detected before chemotherapy and 1,2,3 weeks after chemotherapy with 2D-STI; the GLS×LVtw was calculated. Results:There were no significant differences in the general clinical parameters of the subjects between normal control group and ANTH chemotherapy group before chemotherapy (P>0.05);the values of GLS, GRS and GCS of the patients in ANTH chemotherapy group after ANTH chemotherapy were decreased than those in normal control group and before ANTH chemotherapy(P<0.05),and GLS had the most obvious change. The GLS,GRS,GCS and GLS×LVtw of the patients after 3 cycles of chemotherapy in ANTH chemotherapy group were decreased (P>0.05).Four patients meet the diagnostic criteria of cardiac toxicity in the couse of chemotherapy.The sensitivity was 94%, the specificity was 66.7%, and the maximal Youden index was 0.667 when the △ GLS×LVtw=-64.53%×° was used as the cut-off point in predicting the occurrence of myocardial toxicity. Conclusion:2D-STI can detect the early changes of biomechanical parameters of left ventricular myocardium with highly sensitive in predicting early myocardial toxicity and early cardiac dysfunction caused by ANTH chemotherapy. It may be an effective way to predict the early myocardial toxicity of ANTH chemotherapy in the future.

Key words: strain, twist, two dimension speckle tracking imaging, anthracycline, cardiotoxicity, cardiac function