血清前白蛋白在肝细胞癌患者肝切除术后复发风险评估中的应用

doi:10.13481/j.1671-587x.20150337

Abstract

Abstract:

Objective To analyze the risk factors associated with the recurrence in the patients with hepatocellular carcinoma (HCC), and to evaluate the value of serum prealbumin (PA) in predicting the recurrence in the patients with HCC after operation. Methods A retrospective study of the 143 patients, diagnosed by pathology with HCC after hepatectomy (solitary, tumor size≤5 cm and no metastases or major vascular invasion), was performed and the patients were divided into non-complication group and complication group by the occurrence of postoperative complication.The differences that related to tumor recurrence in two groups were evaluated using Kaplan-Meier curves. Results The patients with postoperative complications showed a higher descend rang of PA (P<0.05).The overall median disease free survival(DFS) and the rate of recurrence of 143 patients were 43 months and 44.7%, respectively. The 1-, 2-, 3- year recurrence rates of the patients after hepatectomy were 29%, 39% and 49%, respectively.The postoperative DFS rates of 1-, 2-, 3- year were 67%, 52%, and 47%, respectively, in the patients with HBV-DNA<10³IU·mL^-1, while they was 67%, 52%, and 47% in the patients with HBV-DNA≥10³IU·mL^-1.The postoperative DFS rate of 1-, 2-, 3- year were 91%, 81%, 64% respectively in the patients with PA decline <43%, while they were 66%, 55%, and 47% in the patients with decline PA≥43%. Conclusion The HBV-DNA level and the decline of postoperative PA are the risk factors of recurrence HCC of after hepatectomy.The recurrent time of the patients with HCC varies with the risk factors.

Key words: liver neoplasms, prealbumin, prognosis, hepatitis B virus

CLC Number:

R735.7

YU Lihan, XIE Feng, ZHENG Tao, FU Jun, YAN Long, YANG Jiamei. Application of serum prealbumin in evaluation on recurrence risk of patients with hepatocellular carcinoma after hepatectomy[J].Journal of Jilin University Medicine Edition, 2015, 41(03): 631-635.

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Application of serum prealbumin in evaluation on recurrence risk of patients with hepatocellular carcinoma after hepatectomy

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