Journal of Jilin University Medicine Edition ›› 2015, Vol. 41 ›› Issue (05): 969-973.doi: 10.13481/j.1671-587x.20150516

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Correlation between expression of programmed cell death-ligand 1 protein and prognosis of lung cancer:A Meta-analysis

LI Shimeng1, PAN Baoxiang2, LI Tong3, XIE Feng1, WANG Hai1   

  1. 1. Department of Clinical Laboratory, China-Japan Union Hospital, Jilin University, Changchun 130033, China;
    2. Department of Stomatology, Nanhu Campus Hospital, Jilin University, Changchun 130012, China;
    3. Department of Radiology, China-Japan Union Hospital, Jilin University, Changchun 130021, China
  • Received:2015-04-24 Online:2015-09-28 Published:2015-09-29

Abstract:

Objective To explore the value of the expression of programmed cell death-ligand 1(PD-L1) protein in evaluation on the prognosis of lung cancer,and to provide the basis for evaluation on the prognosis of lung cancer. Methods PubMed,EMbase,CNKI and WanFang database were searched for collecting retrospective cohort studies on the relationship between of PD-L1 expression and the lung cancer,and the relevant articles were also retrieved from inception to November 2014. Two reviewers independently screened the articles,extracted the data and evaluated the quality.The results of Meta-analysis were analyzed by Stata 11.0 software,and the publication bias of paper was evaluated by means of Begg's funnel plot and Egger's methods. Results Finally 9 cohort studies involving 1 306 patients were included.The Meta-analysis results showed that there was no correlation between the PD-L1 protein expression and the prognosis of the patients with lung cancer(HR=1.28,95%CI:0.78-2.09). Then subgroup analyses results showed that high level of PD-L1 led to poor overall survival in Chinese patients(HR=2.31,95%:1.73-3.10). Conclusion High level of PD-L1 protein expression is the risk factor of lung cancer prognosis in the Chinese patients.

Key words: lung neoplasms, programmed cell death-ligand 1, prognosis, survival rate, Meta-analysis

CLC Number: 

  • R734.2