Journal of Jilin University Medicine Edition ›› 2016, Vol. 42 ›› Issue (01): 7-10.doi: 10.13481/j.1671-587x.20160102

Previous Articles     Next Articles

Effects of SUMO and proteins modified by SUMO on occurrence of malignant gliomas

QI Ling1, WANG Weiyao1, ZHENG Zhonghua1, ZHANG Yizhong1, ZHAO Liwei1, ZHONG Xiuhong1, ZHAO Donghai1, YANG Shuyan1, YANG Ningjiang1, REN Kuang2, YU Hongquan3   

  1. 1. Department of Pathology, Jilin Medical University, Jilin 132013, China;
    2. Department of Pharmacology, Jilin Medical University, Jilin 132013, China;
    3. Department of Neurosurgery, First Hospital, Jilin University, Changchun 130021, China
  • Received:2015-07-01 Published:2016-01-26

Abstract:

Objective: To observe the expressions of small ubiquitin-related modifier protein (SUMO)and related proteins modified by SUMO in the malignant gliomas tissue,and to explore the relationship between sumolation and the occurrence of malignant glioma.Methods: Two samples of normal brain tissues and malignant glioma tissue were prepared as control group and malignant glioma group. The expressions of SUMO1,SUMO2,Aos1,Uba2,UBC9,PIAS1,PIAS2,PIAS3 and Pc2 proteins were detected by Western blotting assay.Results: Compared with control group,the expression levels of SUMO1,SUMO2, Aos1,UBC9 and PIAS3 proteins in malignant glima group were significantly increased (P<0.01), but the expression levels of Uba2,PIAS1 and PIAS2 proteins were decreased(P<0.01). Conclusion: SUMO and poteins modified by SUMO may play an important role in the occurrence of malignant gliomas.

Key words: small ubiquitin-related modifier protein, malignant glioma, gene expression

CLC Number: 

  • R739.41