9种中药注射剂联合肝动脉插管化疗栓塞术治疗原发性肝癌的网状Meta分析

doi:10.13481/j.1671-587x.20160615

Abstract

Abstract:

Objective: To evaluate the effectiveness of 9 kinds of traditional Chinese herb injections combined with transcatheter arterial chemoembolization (TACE) in the treatment of hepatocellular carcinoma and improvement of life quality of the patients using network Meta-analysis.Methods: The Cochrane Library, PubMed, EMbase and CBM, VIP Chinese Journal Database, Wanfang database, and CNKI database were searched by computer. The retrieval time for each database was from establishment time to December 30, 2015. The literature were screened according to the pre-established inclusion and exclusion criteria, and the qualities of these included studies were evaluated. R software was used for statistical analysis and the results of randomized controlled trial (RCTs) were combined and sorted by network Meta-analysis.Results: A total of 86 RCTs including 5 791 patients were finally included. Based on the probabilistic ranking results, the total effective rates were arranged in the descending order, Cantharidin Injection (OR=5.60, 95%CI:3.55-8.84, P=0.920), Kanglaite Injection (OR=5.66, 95%CI:2.96-10.82, P=0.906), Elemene injection (OR=3.34, 95%CI:1.77-6.32, P=0.601), Compound Kushen Injection (OR=2.86, 95%CI:1.84-4.46, P=0.478), Brucea Javanica Oil Injection (OR=2.85, 95%CI:1.94-4.19, P=0.475), Cinobufacini Injection(OR=2.79, 95%CI:2.02-3.85, P=0.452), Delisheng Injection (OR=2.74, 95%CI:1.22-6.15, P=0.448), Aidi Injection (OR=2.71, 95%CI:2.12-3.47, P=0.418) and Kangai Injection (OR=2.37, 95%CI:1.55-3.66, P=0.301). The probabilities of improvement of life quality were ranked from high to low order, Aidi Injection (OR=3.06, 95%CI:1.25-7.47, P=0.669), Kangai Injection (OR=3.38, 95%CI:0.50-22.74, P=0.655), Kanglaite Injection (OR=2.09, 95%CI:0.21-21.38, P=0.599), Delisheng Injection (OR=3.33,95%CI:0.05-210.09, P=0.586) and Cinobufagin Injection (OR=2.39,95%CI:0.47-12.26, P=0.556), Brucea Javanica Oil Injection (OR=2.25,95%CI:0.74-6.81, P=0.547), Cantharidin Injection (OR=1.82,95%CI:0.62-5.35, P=0.464), Elemene Injection (OR=2.20,95%CI:0.08-62.31, P=0.403) and Compound Kushen Injection (OR=1.26,95%CI:0.37-4.27, P=0.325).Conclusion: Cantharidin Injection, Kanglaite Injection, and Elemene Injection are more relatively effective than the other six kinds of traditional Chinese herb injections. Aidi Injection, Kangai Injection, and Kanglaite Injection can improve the life quality better than the other six kinds of traditional Chinese herb injections.

Key words: Chinese herb injection, hepatocellular carcinoma, network Meta-analysis, transcatheter arterial chemoembolization

CLC Number:

R273

SU Yingying, LIU Yingyu, ZHANG Yangyu, MA Yue, YANG Guang, YOU Yueyue, FU Yingli, KOU Changgui. Network Meta-analysis of 9 kinds of Chinese herb injections combined with transcatheter arterial chemoembolization in treatment of hepatocellular carcinoma[J].Journal of Jilin University Medicine Edition, 2016, 42(06): 1126-1131.

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Network Meta-analysis of 9 kinds of Chinese herb injections combined with transcatheter arterial chemoembolization in treatment of hepatocellular carcinoma

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