系统性红斑狼疮伴人巨细胞病毒IgM抗体阳性与阴性患者的临床特征比较

doi:10.13481/j.1671-587x.20160625

Abstract

Abstract:

Objective: To compare the clinical characteristics between the systemic lupus erythematosus (SLE) patients with positive human cytomegalovirus (HCMV)-IgM antibody and negative HCMV-IgM antibody, and to provide basis for the clinical diagnosis and treatment of SLE.Methods: A total of 63 SLE patients with positive HCMV-IgM and 66 SLE patients with negative HCMV-IgM were selected.The patients who had never used corticosteroid hormone or immunosuppressive drugs were included in initial treatment group(n=48),while those who used either of them were included in retreatment group(n=81).The incidence of clinical manifestations,SLE disease activity index (SLEDAI), absolute counts of CD4⁺ T and CD8⁺T lymphocytes,and CD4⁺/CD8⁺ ratio of the patients in two groups were compared.Results: The anemia,fever,liver dysfunction,leukopenia, and rash were the most common clinical manifestations of the SLE patients.The incidence rates of rash,arthritis,serositis and renal dysfunction and SLEDAI in positive HCMV-IgM group were higher than those in negative HCMV-IgM group (P<0.05). Compared with negative HCMV-IgM group,the absolute count of CD4⁺T lymphocytes was decreased,and the absolute count of CD8⁺ T lymhocytes was increased in positive HCMV-IgM group (P>0.05). The incidence rates of rash and arthritis of the patients with positive HCMV-IgM in initial treatment group were higher than those patients with negative HCMV-IgM (P<0.05). The incidence rates of clinical manifestations of the patients with positive HCMV-IgM and with negative HCMV-IgM in retreatment group had no significant differences(P>0.05).Conclusion: The clinical manifestations of the SLE patients with positive and negative HCMV-IgM are different,and the manifestations of patients with positive HCMV-IgM are more serious.

Key words: human cytomegalovirus, T lymphocyte, systemic lupus erythematosus, systemic lupus erythematosus disease activity index

CLC Number:

R593.24

LIU Weiwei, ZHANG Xiaoli, WANG Xiaofei. Comparisonof clinical characteristics between HCMV-IgM positive and HCMV-IgM negative patients with systemic lupus erythematosus[J].Journal of Jilin University Medicine Edition, 2016, 42(06): 1178-1182.

References

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Comparisonof clinical characteristics between HCMV-IgM positive and HCMV-IgM negative patients with systemic lupus erythematosus

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