Journal of Jilin University Medicine Edition ›› 2016, Vol. 42 ›› Issue (02): 311-315.doi: 10.13481/j.1671-587x.20160223

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Expression of CTLA-4 in T lymphocytes of patients with glioma and its clinical significance

FAN Ruitai, ZHANG Heng, WANG Xin, GU Hao   

  1. Department of Radiotherapy, First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China
  • Received:2015-08-12 Published:2016-03-31

Abstract:

Objective: To investigate the correlation between the CTLA-4 expression in the peripheral blood CD4+ and CD8+ T cells in the patients with glioma and glioma WHO classification and operation, and to clarify the clinical significancesof CTLA-4.Methods: 60 patients with glioma from our hospital were selected as glioma group, and 46 healthy volunteers were used as control group.Then the CTLA-4 expression levels in the peripheral blood CD4+ and CD8+ T cells of the subjects in glioma group and control group were detected by fluorescence-activated cell sorting (FACS) and the relationship between CTLA-4 and glioma WHO classification and surgery was analyzed.Results: The CTLA-4 expression levels in CD4+ and CD8+ T cells in peripheral blood of the patients in glioma group were higher than those in control group(P<0.01).The CTLA-4 expression level in the patients with grade Ⅳ glioma was the highest, the expression level of the patients with grade Ⅳ glioma was higher than that of the patients with grade Ⅲ glioma(P<0.01), and the expression level of grade Ⅲ the patients with was higher than that of the patients with grade Ⅱ(P<0.01).The expression level of CTLA 4 in CD4+ and CD8+ T cells of the patients with glioma after operation was lower than beforeoperation(P<0.01).Conclusion: The CTLA-4 expression levels in the peripheral blood CD4+ and CD8+ T cells are increased with the increasing of malignancy degree of the patients with glioma, and it has a promotion role in the occurrence of development of glioma.

Key words: glioma, T lymphocyte, cytotoxic T-lymphocyte associated antigen-4

CLC Number: 

  • R739.41