Abstract: Objective: To study the effects of compound schisandra extracts (CSE) (schisandra,astragalus,acanthopanax,and rhodiola)on the exhaustive swimming time and the levels of blood urea nitrogen(BUN),serum lactic acid(LD),liver glycogen and muscle glycogene,superoxide dismutase(SOD)activity,and malonaldehyde(MDA) level in the mice and to charify its anti-fatigue effect and the mechanism. Methods: Eighty male ICR mice were randomly divided into blank control group, 50 mg·kg^-1 CSE group,100 mg·kg^-1 CSE group,and 200 mg·kg^-1CSE group;there were 20 mice in each group. The mice were administered orally for 30 d.Then 10 mice were randomly selected for exhaustive swimming test in each group and the exhaustive swimming time of the mice was recorded.The remaining 10 mice in each group were used for 90 min swimming,then all the mice were sacrificed and the blood and tissue samples were taken for the measurement of the levels of BUN,LD,liver glycogen and muscle glycogen,the SOD activity and MDA level;the total inhibitory rate of oxidation of CSE in vitro was determined by linoleic acid-ferric thiocyanate method. Results: Compared with blank control group,the exhaustive swimming time of the mice in 50,100,and 200 mg·kg^-1 CSE groups were significantly increased (P<0.01); the levels of BUN and LD of the mice in 100 and 200 mg·kg^-1 CSE groups were significantly decreased (P<0.05 or P<0.01);the levels of liver glycogen and muscle glycogen of the mice in 100 and 200 mg·kg^-1 groups were significantly increased(P<0.05 or P<0.01); whereas the SOD activities were significantly increased and the levels of MDA were decreased(P<0.05 or P<0.01).Compared with 100 mg·kg^-1 CSE group,the levels of serum BUN and LD of the mice in 200 mg·kg^-1 CSE group were decreased (P<0.01), and the levels of liver glycogen and muscle glycogen were increased(P<0.05).The total inhibitory rate of oxidation of 5 g·L^-1CSE was 76.94%. Conclusion: CSE has an anti-fatigue effect and the mechanism may be related to anti-oxidation effect.

Key words: mice,ICR, schisandra, anti-fatigue, anti-oxidation, lactic acid