β-tubulin Ⅲ在结肠腺癌组织中的表达及其临床意义

doi:10.13481/j.1671-587x.20170421

Abstract

Abstract: Objective: To detect the expression and clinical significance of β-tubulin Ⅲ in cancer tissue of the patients with colon adenocarcinoma,and to explore its clinical significance.Methods: A total of 111 colon adenocarcinoma tissue samples were obtained. According to the location of β-tubulin Ⅲ positive cells, all patients were divided into front group (n=72) and non-front group (n=39). The positive expression rate of β-tubulin Ⅲ in the patients with colon adenocarcinoma was detected with immunohistochemistry. The correlations among the expression of β-tubulin Ⅲ and gender,age,tumor differentiation, clinical stage, lymph node metastasis, recurrence and death were analyzed.Results: The expression levels of β-tubulin Ⅲ had no significant differences between the patients with different gerder,age,lymph node metastasis,clinical stages,death and recurrence.The positive expression rates of β-tubulin in cancer tissue of the patients had significant difference between front and non-front groups (χ²=8.76, P=0.01). Lowly-to-moderately differentiated tissue was more common in front group, and highly-differentiated tissue was more common in non-front group(χ²=6.88, P=0.03). There were significant differences in the expression levels of β-tubulin Ⅲ between cancer tissues with different differentiation degrees (χ²=5.74, P=0.04). In non-front group, lymph node metastasis was closely correlated with the expression of β-tubulin Ⅲ (χ²=6.02,P=0.05). The resultsof immunohistochemical staining showed that the β-tubulin Ⅲ positive-expressing cells were colored brown-yellow. The number of cells with positive β-tubulin Ⅲ expression was significantly increased in highly differentiated tissue compared with low-differentiated tissue.Conclusion: The expression of β-tubulin Ⅲ is closely related to tumor differentiation in colon adenocarcinoma tissue. The highly differentiated colon adenocarcinoma tissue is more common in non-front group in which the expression of β-tubulin Ⅲ is related to lymph node metastasis.

Key words: colonic neoplasms, adenocarcinoma, Β-tubulin Ⅲ, immunohistochemistry

CLC Number:

R735.35

SHI Junzhong, ZHUANG Jianbin, ZHANG Chuanshan, LIU Xianming, KONG Dalu. Expression of β-tubulin Ⅲ in colon adenocarcinoma tissue and its clinical significance[J].Journal of Jilin University Medicine Edition, 2017, 43(04): 770-775.

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Expression of β-tubulin Ⅲ in colon adenocarcinoma tissue and its clinical significance

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