Abstract: Objective: To report two cases of esophageal granular cell tumor treated by endoscopic submucosal dissection, and to improve the clinical awareness of the disease. Methods: The results of endoscope and ultrasonography endoscope of 2 cases were retrospectively analyzed. A preliminary diagnosis of the 2 cases was esophageal submucosal protruded lesion. The patients underwent endoscopic submucosal dissection and the tumors were removed completely. Firstly, the lesion border was marked and then hyaluronic acid was injected into submucosa to uplift the lesion sufficiently. Secondly, the mucosa was circumferentially incised along the marked points, and then the lesion was dissected along the submucosal layer gradually to the whole. Finally, necessary hemostatic was undertaken and the wound was clipped with titanium. Results: The pathological results after operation represented that the cells were polygonal or fusiform, rich in cytoplasm and had a dichromatic granular substance, and the nuclei were small.The immunohistochemical results showed S-100(+),NSE(+)/(-),CK(-),SMA(-),CD117(-),desmin(-) and proved that 2 cases of tumors were esophageal granular cell tumor. Two patients recovered smoothly after operation. They underwent endoscopic examination 16 months after operation, and no local recurrence or metastasis was founded. Conclusion: Endoscopic submucosal dissection is a safe and effective treatment of esophageal granular cell tumor,and the postoperative prognosis is good.

Key words: esophageal granular cell tumor, endoscopic ultrasonography, immunohistochemistry, endoscopic mucosa resection, endoscopic submucosal dissection