重组人生长激素治疗前后糖尿病足患者血清中IGF-1、IGFBP-3和血浆蛋白水平的变化及其意义

doi:10.13481/j.1671-587x.20170626

Abstract

Abstract: Objective:To detect the levels of serum insulin-like growth factor 1 (IGF-1), insulin-like growth factor binding protein 3 (IGFBP-3) and the plasma proteinsof the patients with diabetic foot (DF), and to investigate the therapeutic effect of recombinant human growth hormone (rhGH) in the DFpatients. Methods:The DF patients (DF group,n=40), diabetes mellitus patients (DM group,n=40) and healthy adults (normal control group,n=40) were selected. The patients in DF group were divided into rhGH treatment group and conventional treatment group according to the treatment willingness(n=20).The patients in rhGH treatment group recevied 0.4 IU·kg^-1·d^-1 rhGH injection subcutaneously for 15 d, the interval between two courses was 5 d,with a total of 3 courses of treatment. The patients in convention treatment group received subcutaneous injection of the same dose of saline.The general clinical data before and after treatment, the serum IGF-1 and IGFBP-3 levels,the constitution of disease grading of patients, the levels of plasma TP and TRF, FBG, and the efficiency rate and wound healing time of the subjects in DF group and normal control group were detected. Results:The levels of serum IGF-1 and IGFBP-3 of the patients in DF group were significantly lower than those in DM group and normal control group (P<0.01); the serum levels of IGF-1 and IGFBP-3 of the patients in DM group were significantly lower than those in normal control group (P<0.05).After treatment, the serum levels of IGF-1, IGFBP-3 and plasma TP,TRF of the patients in rhGH treatment group were significantly increased compared with before treatment (P<0.05),and they were higher than those in conventional treatment group after treatment (P<0.05).There was no significant difference in the FBG levels of the subjects between DM group and normal control group(P>0.05).The effective rate of the patients in rhGH treatment group was higher than that in conventional treatment group (P<0.05). Conclusion:The efficiency of DF patients can be improved after treated with rhGH, and it is suitable for clinical promotion.

Key words: total protein, recombinant human growth hormone, insulin-like growth factor 1, transferrin, diabetic foot

CLC Number:

R587.1

SHANG Tao, REN Yanli, LI Jing, ZHANG Ying. Changes of serum levels of IGF-1, IGFBP-3 and plasma proteins of patients with diabetic foot before and after recombinant human growth hormone therapyand their significances[J].Journal of Jilin University Medicine Edition, 2017, 43(06): 1209-1214.

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Changes of serum levels of IGF-1, IGFBP-3 and plasma proteins of patients with diabetic foot before and after recombinant human growth hormone therapyand their significances

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