Abstract: Objective:To explore the differences in the positive rates of specific-IgE(sIgE) of the common allergens between the cow's milk protein allergy (CMPA) and healthy infants and the distribution characteristics of positive sIgE of common allergens in the CMPA infants,and to provide basis for comprehensive intervention of the CMPA infants. Methods: A total of 156 cases of CMPA and 318 cases of healthy infants were selected as the subjects. The serum sIgE and total IgE levels of common allergens of the infants in two groups were detected by enzyme-linked immunosorbent assay. The differences in the positive rates of serum sIgE of common allergens and total IgE of the infants in two groups were compared. Results: There were no statistical differences in the positive rates of serum sIgE and total IgE for common allergens of the infants between CMPA group and healthy group(P>0.05).The major food allergens with high positive rates of sIgE in CMPA group were cow's milk(44.2%),egg white(10.3%) and cashew nut(5.1%), and the inhale allergens with high positive rates of sIgE were cat hair(21.2%), dog hair(9.6%) and house dust mite(4.5%).While for the healthy infants, the major food allergens with high positive rates of sIgE were cow's milk(45%),egg white (14.2%)and cashew nut(6.0%),and the inhale allergens with high positive rates of sIgE were cat hair(25.8%),dog hair(14.5%)and fungus combinations(4.5%). The analysis in different age groups (<1 year old and 1-2 years old) showed that there were no statistical differences in the positive rates of serum sIgE and total IgE for common allergens of the infants between CMPA group and healthy group(P>0.05). Conclusion: There are no significant differences in the serum sIgE and total IgE positive rates between the CMPA and healthy infants. The detection of serum sIgE and total IgE of common allergens is of little clinical significance for the CMPA infants.

Key words: cow's milk protein allergy, allergen, sIgE, enzymelinked immunosorbent assay, infant