Abstract: Objective:To investigate the expression levels of tumor markers squamous cell carcinoma antigen (SCC-Ag), carcinoembryonic antigen(CEA), cytokeratin 19 fragment(CYFRA21-1)and D-dimer(D-D) of the patients with non-small cell lung cancer(NSCLC), and to elucidate its clinical value in the early diagnosis of NSCLC. Methods:A total of 200 patients with NSCLC(NSCLC group), 198 patients with benign lung disease(benign lung disease group) and 196 healthy subjects(control group) were selected and the levels of tumor markers and D-D were detected and compared between groups. The receiver operator characteristic curve (ROC) was drawn to analyze the diagnostic values of different tumor markers, D-D, and joint indicators in the patients with NSCLC. Results:The levels of tumor markers and D-D of the patients in NSCLC group were significantly higher than those in benign lung disease group and control group (P<0.01). The level of CEA in lung adenocarcinoma was higher than that in lung squamous cell carcinoma (P=0.005). The levels of SCC-Ag and CYFRA21-1 in lung squamous cell carcinoma were higher than those in lung adenocarcinoma (P=0.008, P=0.004). The levels of tumor markers CEA, CYFRA21-1 and D-D of the patients with stage Ⅲ and Ⅳ NSCLC were significantly higher than those of the patients with stage Ⅰ and Ⅱ NSCLC (P<0.05). The ROC curves showed that area under curve(AUC)of SCC-Ag was higher than other single indexes(AUC=0.805);the sensitivity and specificity were 85.42% and 64.21%, respectively. The diagnostic efficacy of the joint indicators was better than that of each single index (AUC=0.933);the sensitivity and specificity were 86.46% and 88.42%, respectively. Conclusion:Combined detection of tumor markers SCC-Ag, CEA, CYFRA21-1 and D-D can significantly increase the sensitivity and specificity of early diagnosis of NSCLC and has important significance in the early diagnosis of NSCLC.

Key words: carcioma,non-small cell lung, tumor markers, D-dimer, receiver operatating characteristic curve