Abstract: Objective:To explore the correlations between the ultrasound features and the expressions of the molecular biological indicator human epidermal growth factor receptor 2(CerbB-2) and Ki-67 in the patients with breast cancer. Methods:The ultrasonographic characteristics and paraffin section materials of 107 patients with breast cancer confirmed by pathology were collected. The correlations between the ultrasonographic characteristics and the expressions of CerbB-2 and Ki-67 were analyzed. Results:The positive expression rates of CerbB-2 and Ki-67 in breast cancer tissue were 73.83%(79/107) and 81.21%(87/107), respectively;the expressions of CerbB-2 and Ki-67 were positively correlated(r=0.264,P=0.001).There were obvious correlations between the edge, size, shape, orientation, hyper-echoic halo, rear echo attenuation,micro calcification, flow signal 2-3 grade of breast cancer and the expression of CerbB-2 (P<0.05).There were obvious correlations between the aspect ratio >1, hyper-echoic halo, rear echo attenuation,micro calcification, flow signal 2-3 grade of breast cancer and the expression of Ki-67 (P<0.05). The results of multivariate Cox regression analysis showed that CerbB-2 (⧻)(P=0.002), Ki-67 (⧻)(P=0.006), blood flow 2-3 grade (P=0.036), rear echo attenation (P=0.001),and aspect ratio>1 (P=0.002) were the independent prognostic factors of breast cancer. Conclusion:There are significant correlations between some ultrasound features of breast cancer and the positive expressions of CerbB-2 and Ki-67 in the breast cancer tissue.

Key words: breast neoplasms, human epidermal growth factor receptor 2, Ki-67 protein, ultrasound diagnosis