新型纳米碳对行腹腔镜膀胱癌根治术患者盆腔淋巴结的示踪效果及其安全性评价

doi:10.13481/j.1671-587x.20190319

Abstract

Abstract: Objective:To investigate the tracing effect of new nano-carbon(Kanalin)on the pelvic lymph nodes of the patients with bladder cancer during the laparoscopic radical cystectomy(RC), and to explain the significance of its application in the precision surgical treatment. Methods:A total of 44 patients with bladder cancer who underwent RC were divided into tracer group(n=22) and control group (n=22) according to whether Kanalin was used before operation or not. The laparoscopic RC combined with standard pelvic lymph node dissection(LND) was performed in the patients in two groups. The effectiveness evaluation indexes and safety evaluation indexes of the patients in two groups were collected and compared. The effectiveness evaluation indexes included black staining situation of lymph nodes during operation,the number of detected lymph nodes,the black staining rate of lymph nodes,the number of positive lymph nodes, and operation time. The safety evaluation indexes included the blood loss and the incidences of perioperative complications. Results:The black staining effect of lymph nodes of the patients in tracer group was definite and there were no tracer-related side effects and complications during the perioperative period. Compared with control group, the clearance rate and detection rate of lymph nodes of the patients in tracer group were increased (P<0.01). The black staining rate of lymph nodes of each case was higher than 50%, even up to 85%. There were no significant differences in the number of positive lymph nodes,the operation time, the blood loss and the perioperative complication rates of the patients between two groups(P>0.05). Conclusion:During the laparoscopic RC, the application of Kanalin for pelvic lymph node tracing is safe, without toxic and side effects;Kanalin is helpful for increasing the intraoperative clearance rates and postoperative pathological detection rates of lymph nodes.

Key words: lymphatic tracer, carbon nanoparticle suspension injection, radical cystectomy, lymph node dissection

CLC Number:

R737.14

MA Jianan, GAO Baoshan, XIAO Ping, ZHANG Yongrui, WU Dawei, AN Wei. Tracing effect of new nano-carbon onpelvic lymph nodes of patients during laparoscopic radical cystectomy and its safety evaluation[J].Journal of Jilin University(Medicine Edition), 2019, 45(03): 582-586.

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Tracing effect of new nano-carbon onpelvic lymph nodes of patients during laparoscopic radical cystectomy and its safety evaluation

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