整联蛋白α亚基1基因单核苷酸多态性与非贲门胃癌发病风险的关联性分析

doi:10.13481/j.1671-587x.20190318

Abstract

Abstract: Objective:To investigate the associations between single nucleotide polymorphisms (SNP) of integrin α-subunit 1 (ITGA1) gene and the risk of non-cardia gastric cancer, and to elucidate the roles of ITGA1 gene polymorphisms in the risk of non-cardia gastric cancer. Methods:The case-control study design was used. A total of 288 patients with non-cardia gastric cancer were selected as case group, and 281 community physical examinees were selected as control group in Han population in Boatou City in Inner Mongolia Autonomous Region. The SNP of rs1862610, rs2432143, and rs2447867 sites of subjects in two groups were genotyped by using TaqMan method,and the haplotype was constructed by Haploview software 4.0. The odds ratio (OR) and 95% confidence intervals (95%CI) were measured by conditional Logistic regression analysis to evaluate the correlations between the frequencies of allele, genotype, and haplotypes and the susceptibility to non-cardia gastric cancer. Results:The SNP of rs1862610, rs2432143, and rs2447867 sites in ITGA1 gene were not associated with the risk of non-cardia gastric cancer (P>0.05). The SNP of rs1862610 and rs2432143 sites were in strong linkage disequilibrium(D'=1) and formed a block. Compared with those who carried haplotype CT, those who carried haplotype CC had an increasing risk of non-cardiac gastric cancer(CC vs CT:OR=1.42, 95% CI:1.02-1.99). Conclusion:The ITGA1 gene polymorphisms may play a role in the risk of non-cardia gastric cancer in Han population in Baotou in Inner Mongolia Autonomous Region. The risk of non-cardia gastric cancer in the person who carries the SNP rs1862610-rs2432143 CC haplotype is increased.

Key words: integrin α-subunit 1, polymorphism, stomach neoplasms, susceptibility

CLC Number:

R394.5

GAO Fang, MA Licong, DONG Wenjie, TIAN Xuyang, DANG Tong, JIA Yanbin. Analysis on association between single nucleotide polymorphisms of ITGA1 gene and risk of non-cardia gastric cancer[J].Journal of Jilin University(Medicine Edition), 2019, 45(03): 577-581.

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Analysis on association between single nucleotide polymorphisms of ITGA1 gene and risk of non-cardia gastric cancer

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