不同糖代谢状态人群血清CTRP3和25(OH) D水平及其与胰岛素抵抗的关系

doi:10.13481/j.1671-587x.20190425

Abstract

Abstract: Objective:To detect the serum levels of CTRP3 and 25(OH) D in the individuals with different glucose metablism states,and to discuss the influence factors and analyze their relationships with insulin resistance(IR). Methods:Forty-four patients newly diagnosed T2DM(T2DM group),42 patients with impaired glucose regulation(IGT group),and 54 cases of normal controls(normal control group) were selected.The serum CTRP3, FPG,HbA1c,FIns,TG,TC,HDL-C, LDL-C,FIns of the subjects in various groups were determined, respectively;the BMI,HOMA-IR,HOMA-β were calculated.Pearson correlation analysis was used to analyze the correlation between two factors and multivariate stepwise regression analysis was used to analyze the influencing factors of HOMA-IR and HOMA-β. Results:Compared with normal control group, the serum levels of HDL-C, 25(OH)D and HOMA-β of the patients in IGT group were significantly decreased (P<0.05); the levels of serum FPG, HbA1c, TG, TC, FIns and BMI, HOMA-IR of the patients in T2DM group were significantly increased (P<0.05), while the levels of serum CTRP3, HDL-C, 25(OH)D and HOMA-β were significantly decreased(P<0.05). Compared with IGT group, the levels of serum FPG, HbA1c, TG, FIns, and HOMA-IR of the patients in T2DM group were significantly increased (P<0.05), and the level of serum HDL-C and HOMA-β were significantly decreased (P<0.05).The serum CTRP3 level was negatively correlated with the levels of HbA1c, FIns and HOMA-IR (r=-0.391, P<0.05; r=-0.198, P<0.05; r=-0.481, P<0.05); the 25(OH)D level was negatively correlated with the TG, FPG levels and HOMA-IR (r=-0.209, P<0.05; r=-0.406, P<0.05; r=-0.306, P<0.05), and positively correlated with HOMA-β (r=0.329, P<0.05) in the different glucose tolerance individuals. HbA1c and CTRP3 were the independent influencing factors of HOMA-IR, and 25(OH)D, FPG and HbA1c were the independent influencing factors of HOMA-β. Conclusion:The serum CTRP3 and 25(OH)D levels are negatively correlated with IR,and they have the inhibitory effects in the occurrence and development of diabetes mellitns.

Key words: glucose metabolism, C1q/TNF related protein 3, 25 hydroxy vitamin D, insulin resistance

CLC Number:

R587.2

LIAO Xin, DENG Fanqu, SONG Meihui, GAO Lin, ZHANG Han, ZHANG Lin, WANG Xuemei, ZHANG Ying, ZHAO Yu. Relationship between serum levels of CTRP3, 25(OH)D and insulin resistance in individuals with different glucose metabolism states[J].Journal of Jilin University(Medicine Edition), 2019, 45(04): 887-892.

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Relationship between serum levels of CTRP3, 25(OH)D and insulin resistance in individuals with different glucose metabolism states

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