蛋白聚糖和ADAMTS-1在多囊卵巢综合征患者血清中的表达及其临床意义

doi:10.13481/j.1671-587x.20190232

Abstract

Abstract: Objective: To determine the expressions of Versican and a distintegrin and metalloprotease with thrombospondin type 1 motifs(ADAMTS-1) in serum in the polycystic ovary syndrome (PCOS) patients, and to clarify their roles in the pathogenesis of PCOS.Methods: A total of 80 patients with PCOS (PCOS group) and 100 healthy women (control group) were selected.The heights and body weights of the subjects in two groups were measured; and the body mass index(BMI) was calculated.The levels of serum Versican and ADAMTS-1 of the subjects in two groups were measured by enzyme-linked immunosorbent assay(ELISA) method.The levels of serum follicle stimulating hormone(FSH),luteinizing hormone(LH),testosterone(T),fasting blood glucose(FBG),fasting insulin of the subjects in two groups were detected; insulin resistance was evaluated according to Homeostasis Model Assessment of Insulin Resistance (HOMA-IR).The correlations between Versican,ADAMTS-1 and the metabolic indexes were analyzed by Pearson linear correlation analysis.Results: The serum Versican level of the paticnts in PCOS group was significantly decreased compared with control group (P=0.004);the serum ADAMTS-1 level was also decreased (P<0.01). The sensitivities,the specificities and the area under receiver operating characteristic (ROC) curve (AUC) of Versican and ADAMTS-1 in prediction of PCOS were 76.74% vs 63.64% (P=0.018),52.94% vs 40.73% (P=0.009) and 0.675 (0.550-0.795) vs 0.714(0.601-0.827) (P=0.032), respectively. The correlation analysis showed that in PCOS group the serum level of Versican of the patients was negatively correlated with FBG(r=-0.738,P=0.022), and ADAMTS-1 was negatively correlated with FBG(r= -0.524,P=0.043).Conclusion: Versican and ADAMTS-1 lowly express in the patients with PCOS. They are negatively correlated with the insulin resistance.They may play inhibitory effects in the occurrence of PCOS.

Key words: Versican, a distintegrin and metalloprotease with thrombospondin type 1 motifs, polycystic ovary syndrome, insulin resistance, fasting blood glucose

CLC Number:

R711.75

JIN Aihong, ZHOU Xiaping, YU Zhiying. Expressions of Versican and ADAMTS-1 in polycysticovary syndrome patients and their clincal significances[J].Journal of Jilin University(Medicine Edition), 2019, 45(02): 400-404.

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Expressions of Versican and ADAMTS-1 in polycysticovary syndrome patients and their clincal significances

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