Abstract: Objective: To detect the thromboelastrography (TEG) parameters, mean platelet volume(MPV)/platelet count(PC) ratio and plasma fibrinogen(FIB) level in the patients with recurrent spontaneous abortionin(RSA) in non-pregnant state, and to evaluate their predictive values in the disease. Methods: A total of 206 patients with RSA history were selected as observation group and 92 healthy women who underwent prenatal examination during the same period were selected as control group. The TEG parameters, MPV, PC and FIB levels of the subjects in two groups were measured, and the predictive values of relevant indicators in RSA were evaluated. Results: Compared with control group, the setting time (K value) of TEG parameters of the patients in observation group was decreased (P<0.05), the setting angle(α angle) and maximum amplitide(MA value) were increased (P<0.05), and the MPV/PC ratio and FIB level were increased (P<0.05). There was no significant difference in the response time(R value) of TEG parameters of the subjects between two groups (P>0.05).The areas under receiver operating characteristic (AUC) curve of MA value, MPV/PC ratio and FIB level were 0.694, 0.673 and 0.735,respectively. The results showed that the three paramerters had good clinical predictive values in RSA. Conclusion: The K value, α angle, MA value, MPV/PC ratio and FIB level in the RSA patients have changed in the non-pregnant state, which is of great value in the early prediction of RSA.

Key words: recurrent spontaneous abortion, thromboelastography, mean platelet volume, platelet count, fibrinogen