Abstract:

Abstract:Objective To study the cardiac damage of the heroin dependence and withdrawal rats and the influence of myocardial enzymes by purine nucleotide.Methods The rat models of heroin dependence and withdrawal were set up.80 Wistar rats were randomly divided into 8 groups(10 rats of each group):control(C),heroin administration group(H),3 d withdrawal group(W3),9 d withdrawal group(W9),nucleotide group(N),heroin and nucleotide group(HN),nucleotide 3 d group(N3),nucleotide 9 d group(N9).The activities of total creatine kinase(CK),the myocardial isoenzyme of creatine kinase(CK-MB),lactate dehydrogenase (LDH),a-hydroxybutyrate dehydrogenase (HBDH) and m-aspartate aminotransferase (m-AST) in plasma were tested.
Results Compared with control group,the activities of CK,CK-MB,LDH,HBDH and m-AST in 3 d withdrawal group and 9 d withdrawal group were significantly lower (P<0.01,P<0.05),while the activities of  CK,CK-MB,LDH,HBDH and m-AST in heroin administration group,nucleotide group,heroin and nucleotide group didn’t change significantly (P>0.05).And compared with control group,the activities of HBDH in 3 d nucleotide group and 9 d nucleotide group increased significantly (P<0.05,P<0.01),and the activities of CK,CK-MB,LDH and m-AST were considered normal (P>0.05).
Conclusion The heroin has delayed and durative damage to the cardiac muscle,and can’t eliminate immediately after stopping administration；purine nucleiotide can diminish this damage and maintain some plasma myocardial enzymes of heroin dependence  and withdrawal rats in relatively steady condition，and improve the functional status of cardiac muscle cells.

Key words: heroin；purine nucleotide；myocardial enzymes