Abstract:

Abstract:Objective To investigate the genetic association between the PTEN single polymorphisms and laryngocarcinoma in Chinese Han population.Methods The method of PCR-based restriction fragment length polymorphism (PCR-RFLP) analysis was used to detect the genotypes of rs1903858 and rs701848 of PTEN gene in 253 subjects,including 149 sporic laryngocarcinoma patients(case group) and 104 controls(control group).The association between anti-oncogene PTEN single nucleotide polymorphism and laryngocarcinoma was analyzed with SPSS10.0. Results The genotypic frequencies of the 2 SNPs of anti-oncogene PTEN did not deviate from Hardy-Weinberg equilibrium in both case and control groups.The allelic and genotypic frequencies of the 2 SNPs had no remarkable differences between case and control groups (P>0.05).Conclusion Neither rs1903858 nor rs701848 of the PTEN gene has no association with laryngocarcinoma  in Chinese Han population.

Key words: phosphatase and tensin homologue deleted on chromosome ten;polymorphisms, single nucleotide； laryngeal neoplasms