J4 ›› 2010, Vol. 36 ›› Issue (2): 225-228.
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HUO Yan, YUAN Rong-Di, YE Jian, YIN Xiao-Lei, ZHOU Huan
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Abstract:Objective To study the expression of growth associated protein 43 (GAP-43) after optic nerve transection injury in visual system of neonatal rats and its significance. Methods The healthy neonatal SD rats (24 h) were randomly divided into normal control group and optic nerve transection injury group. Immunohistochemical staining technique was used to detect the expressions of GAP-43 in normal and optic nerve transection injury visual system of neonatal rats at 1,3,7,14,28,56 d after birth. Results The positive expression of GAP-43 in normal control group was found in visual system of neonatal rats at developing stage and with the neurons mature the expression of GAP-43 was decreased(P<0.05). The positive expression of GAP-43 in optic nerve transection injury group was found and was higher than that in normal control group.There was no significant change at 1 d,the expression of GAP-43 in optic nerve transection injury group was increased at 3 d and reached peak at 7-14 d,then it was gradually decreased to normal level until 56 d. Conclusion The expression of GAP-43 in visual system of neonatal rats changes with the development. The expression of GAP-43 is increased after optic nerve transection injury. This result suggests that GAP-43 may play an important role in the developing and regeneration of visual system.
Key words: growth associated protein; , visual system;rats,Sprague-dawley
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HUO Yan, YUAN Rong-Di, YE Jian, YIN Xiao-Lei, ZHOU Huan. Expression of growth associated protein-43 after optic nerve transection injury in visual system of neonatal rats[J].J4, 2010, 36(2): 225-228.
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http://xuebao.jlu.edu.cn/yxb/EN/Y2010/V36/I2/225
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