Abstract:

Abstract:Objective To study the chinical characteritics of critical patients cased by  influenza A H1N1 virus,a new pathogen,in order to provide references for diagnosis and treatment.Methods The general clinical data, symptoms, signs, laboratory examinations, diagnosis and treatment methods and results in 24 cases of influenza A H1N1  complicated with severe pneumonia   were analyzed. Results The mean age  of 24 patients was (28.73±9.24) years, in which 2 cases of pregnant women (8.3%), obesity (body mass index (BMI) ≥ 30) 18 cases (75.0%), chronic underlying diseases  2 cases (8.3 %), including 1 case of bronchial asthma, 1 case of post renal transplantation.Fever, sore throat, shortness of breath were the main symptoms of patients. Multiple lung consolidation was found in 22 cases (91.6%). 24 patients were  treated with anti-viral therapy (oseltamivir 75 or 150 mg,oral administration, 2 times　per day), 20 cases with  hormone therapy (83.3%), 18 patients were treated with mechanical ventilation (75.0%), of which 6 cases with mechanical ventilation after endotracheal intubation (25.0%), 2 death (8.3%). Conclusion Influenza A H1N1  complicated with severe pneumonia  mainly occurs in young adults; the pregnant women, obesity, patients with chronic underlying diseases are easily complicated  with severe pneumonia after infection;the  antiviral drugs,  glucocorticoids adjuvant therapy and artificial ventilation should be used as soon as possible. Tension pneumothorax, multiple organ dysfunction and other related complications are the main causes of death.

Key words: influenza A H1N1；severe pneumonia; , clinical analysis