Abstract:

Abstract:Objective
To assess the long-axis regional systolic function of the left ventricle (LV) in patients with type 2 diabetes mellitus ( T2DM) using two-dimensional strain echocardiography（2D-SE）and explore clinical application value of 2D-SE.Methods 30 T2DM patients with normal LV ejection fraction (LVEF≥55%), 30 normal controls were selected.The peak strain of segments in apical long-axis, four-chamber,and two-chamber views were evaluated,and average peak strain in the long axis at basal,middle and apical levels were assessed by automated functional imaging(AFI).Results LVEDV,LVESV,SV and LVEF in T2DM patients and normal  controls were all within normal limits.Furthermore,there was no significant difference between the two groups (P＞0.05).Compared with normal controls, the peak strain at each plane in T2DM patients was significantly reduced (P<0.01).Conclusion The long-axis regional systolic function of  LV in the patients with T2DM is impaired ahead of global systolic function disturbance.     2D-SE may be used to identify early abnormalities of systolic function in T2DM patients with normal LVEF.

Key words: two-dimensional strain echocardiography;diabetes mellitus;left ventricular function