Abstract:

Abstract:Objective To investigate the effects of gliadin on development and function of central nervous system in mice,and elucidate that gliadin is very likely to be an environmental factor for mental disorder.MethodsNewly-weaning BALB/c mice were intragastrically administered with gliadin,and stimulated with stress.The mice were divided into positive anti-gliadin IgA aitibody group and negative anti-gliadin IgA antibody group(n=10).The systemic-toxic effects of animal models induced by gliadin were detected with basic observation,ethological evaluation (Hang test,Balance and coordination test,Open-field test and  Forced swimming test) and the cerebral index was calculated.Results The mice in positive anti-gliadin IgA antibody group had less activity and depression,and the body weight  was lower than that of the mice in negative anti-gliadin IgA antibody group (P<0.05).The results of Balance and coordination test,Open-field test and Forced swimming test showed that the mental status was affected more seriously in positive anti-gliadin IgA antibody  group than that in negative group (P<0.05).The ratio of the cerebellum to whole brain in positive anti-gliadin IgA antibody  group was significantly decreased as compared with negative group (P<0.05).Conclusion The immunological reaction induced by gliadin maybe influence the development and function of central nervous system in mice.

Key words: gliadin；immunological reaction；central nervous system