Abstract:

Abstract:Objective
To investigate the protective effects of total flavonoids of Bidens bipinnata L. (TFB) on acute and chronic liver injury in mice induced by carbon tetrachloride and  mechanisms. Methods Sixty Wistar rats were randomly divided into control group,model group,Hu-Gan-Pian(4 g?kg-1) group and TFB (120，60，30 mg?kg-1) groups. The acute and chronic liver injury model in mice were induced by different dosages and administration times of carbon tetrachloride respectively to study the effects of TFB on liver index,hepatic morphological changes and detect the contents of SOD,MDA,ALT and AST in serum. Results  Compared with model group,the degree of hepatic edema in TFB（120，60，30 mg?kg-1）and Hu-Gan-Pian(4 g?kg-1) groups were decreased（P<0.05 or P<0.01）,the contents of AST,ALT and MDA in serum were decreased（P<0.05 or P<0.01）,and the contents of SOD were increased（P<0.05 or P<0.01）. TFB and Hu-Gan-Pian could ameliorate the pathological lesion. Conclusion TFB has protective effects on carbon tetrachloride-induced acute and chronic liver injury in mice,which may be related to inhibition of lipid oxidation.

Key words: total flavonoids of Bidens bipinnata L.；carbon tetrachloride；acute and chronic liver injury；lipid peroxidation