Abstract:

Abstract:Objective To study the changes of N-terminal pro brain natriuretic peptide(NT-ProBNP) in patients with type 2 diabetes mellitus(T2DM) complicated with  autonomic neuropathy(AN)(T2DAN), and  illustrate the correlation between NT-ProBNP and T2DAN. Methods 40 patients with simple T2DM，35 patients with T2DAN were selected, and 21 healthy subjects were used as control group.  The expressions of  NT-ProBNP in the peripheral blood of the patients and healthy　 subjects were detected with ELISA. Results The levels of NT-ProBNP in T2DAN group were higher than those in  T2DM group (P<0.01) and healthy control group (P<0.01).NT-ProBNP was positively correlated with course, FPG and HｂA1c，HR in horizontal position,change of SBP from supine to standing (r=0.957, P<0.01;r=0.932, P<0.01; r=0.912, r=0.876，P<0.01;r=0.924,P<0.01), but negatively correlated with FC-P,HRV with deep respiration,HRV with postural hange,30:15 ratio,valsalva ratio(r=－0.755, P<0.01; r=－0.766, P<0.01;  r=－0.698, P<0.01; ;r=－0.732, P<0.01;  r=－0.812, P<0.01). Conclusion NT-ProBNP over-expresses and has a clear correlation with  DAN in patients with T2DAN.

Key words: type 2 diabetes mellitus;diabetic autonomic neuropathy;N-terminal pro brain natriuretic peptide